Alexander-Arnold sustained an injury during the second half of Liverpool's penalty shoot-out loss to Paris Saint-Germain in the Champions League round of 16 at Anfield on Tuesday.
The absence of the 26-year-old poses a significant challenge for Liverpool manager Arne Slot, who will be without a recognized right-back for the upcoming match against Newcastle at Wembley on Sunday.
Both Conor Bradley and Joe Gomez, the typical replacements for Alexander-Arnold, are currently in recovery from their own injuries.
“Trent is not available. He will not be there at the final,” Slot informed the media on Friday.
“He is still to be assessed for how long it will take but we do expect him back before the end of the season.”
Alexander-Arnold was omitted from the England squad announced by Thomas Tuchel on Friday in preparation for the World Cup qualifiers scheduled for later in March.
As the holders of the League Cup, Liverpool is striving to secure the first trophy of Slot’s tenure when they compete against Newcastle this weekend.
Additionally, the Reds are on track to match a record 20th English title, having established a 15-point advantage at the top of the Premier League standings.
